Proliferation and tissue organization of human ES cell‐derived cardiomyocytes
نویسندگان
چکیده
منابع مشابه
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Guanghua Yang ([email protected]) Karim Si-Tayeb ([email protected]) Sébastien Corbineau ([email protected]) Rémi Vernet ([email protected]) Régis Gayon ([email protected]) Noushin Dianat ([email protected]) Clémence Martinet ([email protected]) Denis Clay ([email protected]) Gérard Tachdjian ([email protected]) Deborah Burks (dburks@cip...
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Transplantation studies in mice and rats have shown that human embryonic-stem-cell-derived cardiomyocytes (hESC-CMs) can improve the function of infarcted hearts, but two critical issues related to their electrophysiological behaviour in vivo remain unresolved. First, the risk of arrhythmias following hESC-CM transplantation in injured hearts has not been determined. Second, the electromechanic...
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BACKGROUND It has long been thought that mammalian cardiomyocytes are terminally-differentiated and unable to proliferate. However, myocytes in more primitive animals such as zebrafish are able to dedifferentiate and proliferate to regenerate amputated cardiac muscle. METHODOLOGY/PRINCIPAL FINDINGS Here we test the hypothesis that mature mammalian cardiomyocytes retain substantial cellular pl...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.4.a18-d